Endocrine Abstracts

Methods: We retrospectively reviewed the medical notes of 39 patients who received radioiodine treatment (RAI) for thyrotoxicosis from 2004 until February 2010.Results: Thirty (76.9%) patients were females and the median age of diagnosis was 59.5 years. 17.9% had positive family history of thyrotoxicosis; current smokers (31%), ex-smokers (18%); Graves’ disease (56.4%), Multinodular goitre (41%), and unspecified diagnosis (2.6%). 18% of patients had...

Introduction: Endocrinopathies can cause secondary osteoporosis and little is known of the extent of this condition in young adults.Methods: In order to assess the bone health in endocrinopathies in young adults, a retrospective analysis of 25 transitional clinic patients who underwent dual energy X-ray absorptiometry (DEXA scan) was made using case notes and the hospital database.Results: Twenty-three patients were male and the me...

Congenital hypoglycemic hyperinsulinemia (CHI) is a clinical and genetic heterogeneous entity. Clinical manifestations can vary from serious life threatening to milder difficultly identifiable cases. Children who do not react adequate to medical treatment are subject to pancreatic recession. The molecular ethiology are from recessive mutations of the ABCC8 (SUR1) and KCNJ11 (Kir6.2) to dominant mutations of the GCK or GDH genes. Focal dysplasia char...

Aim: To compare the use of glitazones against NICE guidelines. (Glitazone recommended as second line therapy in combination with metformin or sulfonyl urea in patients with intolerance or contra-indications to any of the two, not as monotherpay or triple therapy or in combination with insulin).Methods: Patients on glitazone therapy (n=60) were randomly identified from a pharmacy data base from August to December 2006. Retrospective case note revie...

Introduction: It is well known that struma ovarii, choriocarcinoma and follicular thyroid carcinoma can cause thyrotoxicosis. We report a rare case of a man with carcinomatosis presenting with acute thyrotoxicosis, unilateral proptosis and neck swelling.Case report: A 48-year-old man presented with a 2 weeks history of neck swelling, profuse sweating, heat intolerance, agitation, weight loss and mild unilateral proptosis. He was a smoker with a 20 years ...

PYY is secreted postprandially from the endocrine L-cells of the gastrointestinal tract. PYY3–36, the major circulating form of PYY, reduces food intake in humans and rodents via high affinity binding to the auto-inhibitory NPY receptor, Y2R, within the hypothalamic arcuate nucleus.Aims: To investigate (1) the effects of length of fast on the anorexigenic actions of PYY3–36; (2) the effects of early light phase administrat...

We present the case of a 57 year old male that presented to a tertiary centre with a week’s history of lethargy, muscle cramps and peri-oral paraesthesia. He was otherwise fit and well. His examination revealed no evidence of Chvostek’s, Trousseau’s or tetany. His reflexes were not assessed. Initial electrolyte screening confirmed a hypocalcaemia with a serum adjusted calcium of 1.47 mmol/l (2.2–2.6), his phosphate was elevated at 1.64 mmol/l (0.8–1.5)...

Introduction: Congenital hyperinsulinism (CHI) is a rare genetic disorder of unregulated insulin secretion from the pancreatic β-cells leading to severe hypoglycaemia & permanent neurological deficit if not managed appropriately. Kenotic hypoglycaemia (KH), a diagnosis of exclusion, is by far the most common form of hypoglycemia in children between 1–5 years of age characterized by recurrent episodes of hypoglycaemia and ketosis.Aim: To ide...

BackgroundAdrenal leiomyoma is a rare benign soft tissue tumor, it is even more unusual if presenting bilaterally; 21 cases have been reported in the literature and only six had bilateral involvement; 5 in the pediatric population and only one in an adult patient. Radiological appearance may frequently be confused with malignancy especially if large, calcified and with central necrosis. We report a rare case of bilateral, large, calcified, non-functionin...

IntroductionParathyroid crisis (PC) is a very rare yet fatal clinical condition which mandates urgent intervention. We present a case of parathyroid crisis with severe symptomatic hypercalcemia and multi-organ involvement.Case descriptionA 63-year-old male presented with three days of generalized fatigue, abdominal pain and vomiting. Review of systems revealed constipation and symptoms suggestive of depressio...